Hoehme
Lab • Research group
Systems medicine • AI-based image analysis • Multiscale 3D liver models
Systems medicine • AI-based image analysis • Multiscale 3D liver models
Publications
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2024
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62. |
Daniela González, Gisela Campos, Larissa Pütter, Adrian Friebel, Christian H. Holland, Leonhard Holländer, Ahmed Ghallab, Zaynab Hobloss, Maiju Myllys, Stefan Hoehme, Nadja M. Meindl-Beinker, Steven Dooley, Rosemarie Marchan, Thomas S. Weiss, Jan G. Hengstler, Patricio Godoy (2024) Role of WISP1 in stellate cell migration and liver fibrosis Cells 13(19), 1629; https://doi.org/10.3390/cells13191629 Journal impact factor (2023): 6.0 |
61. |
Reham Hassan, Zaynab Hobloss, Maiju Myllys, Daniela González, Brigitte Begher-Tibbe, Joerg Reinders, Adrian Friebel, Stefan Hoehme, Noha Abdelmageed, Aya A Abbas, Abdel-latief Seddek, Samy AF Morad, Jan G Hengstler, Ahmed Ghallab (2024) Acetaminophen overdose causes a breach of the blood–bile barrier in mice but not in rats Archives of Toxicology 98 (5), 1533-1542 Journal impact factor (2022): 5.7 |
60. |
Reham Hassan, Andrea Gerdemann, Benedikt Cramer, Zaynab Hobloss, Maiju Myllys, Daniela González, Wiebke Albrecht, Adrian Friebel, Stefan Hoehme, Gisela H. Degen, Hans-Ulrich Humpf, Jan G. Hengstler, Ahmed Ghallab (2024) Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1-metabolism in mice and rats Archives of Toxicology 98 (4), 1081-1093 Journal impact factor (2022): 5.7 |
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2023
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59. |
Ahmed Ghallab, Daniela González, Ellen Strängberg, Ute Hofmann, Maiju Myllys, Reham Hassan, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Julia Duda, Carolin Drenda, Franziska Kappenberg, Joerg Reinders, Adrian Friebel, Mihael Vucur, Abdel-latief Seddek, Tahany Abbas, Noha Abdelmageed, Samy A.F. Morad, Walaa Morad, Amira Hamdy, Wiebke Albrecht, Naim Kittana, Mohyeddin Assali, Nachiket Vartak, Christoph van Thriel, Ansam Sous, Patrick Nell, Maria Villar-Fernandez, Cristina Cadenas, Erhan Genc, Rosemarie Marchan, Tom Luedde, Peter Åkerblad, Jan Mattsson, Hanns-Ulrich Marschall, Stefan Hoehme, Guido Stirnimann, Matthias Schwab, Peter Boor, Kerstin Amann, Jessica Schmitz, Jan H. Bräsen, Jörg Rahnenführer, Karolina Edlund, Thomas Reiberger, Mattias Mandorfer, Michael Trauner, Paul A. Dawson, Erik Lindström, Jan G. Hengstler (2023) Inhibition of the Renal Apical Sodium Dependent Bile Acid Transporter Prevents Cholemic Nephropathy in Mice with Obstructive Cholestasis Journal of Hepatology 80 (2), 268-281 Journal impact factor (2021): 30.1 |
58. |
Raly James Perez Custodio, Zaynab Hobloss, Maiju Myllys, Reham Hassan, Daniela González, Jörg Reinders, Julia Bornhorst, Ann-Kathrin Weishaupt, Abdel-latif Seddek, Tahany Abbas, Adrian Friebel, Stefan Hoehme, Stephan Getzmann, Jan G. Hengstler, Christoph Van Thriel, Ahmed Ghallab (2023) Cognitive functions, neurotransmitter alterations and hippo-campal microstructural changes in mice caused by feeding on Western diet Cells 12 (18), 2331 Journal impact factor (2021): 7.7 |
57. |
Stefan Hoehme; Jan Boettger; Seddik Hammad; Brigitte Begher-Tibbe; Petru Bucur; Eric Vibert; Rolf Gebhardt; Jan G. Hengstler; Dirk Drasdo (2023) Digital twin demonstrates regeneration after partial liver hepatectomy to require biomechanical growth control iScience Volume 26, Issue 1, 20 January 2023, 105714 Journal impact factor (2022): 6.1 |
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2022
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56. |
Reham Hassan, Daniela González, Zaynab Hobloss, Lisa Brackhagen, Maiju Myllys, Adrian Friebel, Abdel-latif Seddek, Rosemarie Marchan, Benedikt Cramer, Hans-Ulrich Humpf, Stefan Hoehme, Gisela H. Degen, Jan G. Hengstler, Ahmed Ghallab (2022) Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A Archives of Toxicology (Accepted) Journal impact factor (2022): 5.7 |
55. |
Reham Hassan, Adrian Friebel, Lisa Brackhagen, Zaynab Hobloss, Maiju Myllys, Daniela González, Wiebke Albrecht, Elsayed S. I. Mohammed, Abdel-latif Seddek, Rosemarie Marchan, Cristina Cadenas, Benedikt Cramer, Hans-Ulrich Humpf, Lukas Hartl, Benedikt Simbrunner, Thomas Reiberger, Michael Trauner, Stefan Hoehme, Gisela H. Degen, Jan G. Hengstler, Ahmed Ghallab (2022) Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity Archives of Toxicology 96, pages 2967–2981 Journal impact factor (2022): 5.7 |
54. |
Reham Hassan, Maiju Myllys, Lisa Brackhagen, Zaynab Hobloss, Daniela González, Abdel-latif Seddek, Adrian Friebel, Stefan Hoehme, Rosemarie Marchan, Michael Trauner, Jan G. Hengstler, Ahmed Ghallab (2022) Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins Archives of Toxicology 96, pages 3067–3076 Journal impact factor (2019): 5.1 |
53. |
Adrian Friebel, Tim Johann, Dirk Drasdo, Stefan Hoehme (2022) Guided interactive image segmentation using machine learning and color based data set clustering Bioinformatics 38 (19), 4622-4628 Journal impact factor (2021): 6.9 |
52. |
Ahmed Ghallab, Reham Hassan, Ute Hofmann, Adrian Friebel, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Maiju Myllys, Joerg Reinders, Nina Overbeck, Selahaddin Sezgin, Sebastian Zühlke, Abdel-latif Seddek, Walaa Murad, Tim Brecklinghaus, Franziska Kappenberg, Jörg Rahnenführer, Daniela González, Christopher Goldring, Ian M. Copple, Rosemarie Marchan, Thomas Longerich, Mihael Vucur, Tom Luedde, Stephan Urban, Ali Canbay, Thomas Schreiter, Michael Trauner, Jephte Y. Akakpo, Mojtaba Olyaee, Steven C. Curry, Jan-Peter Sowa, Hartmut Jaeschke, Stefan Hoehme, Jan G. Hengstler (2022) Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity Journal of Hepatology Volume 77, Issue 1, July 2022, Pages 71-83 Journal impact factor (2020): 25.1 Citations GS (10.2022): 5 |
51. |
Christian H. Holland, Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, Cristina Cadenas, Jörg Reinders, Stefan Hoehme, Abdel-latif Seddek, Steven Dooley, Verena Keitel, Patricio Godoy, Brigitte Begher-Tibbe, Christian Trautwein, Christian Rupp, Sebastian Mueller, Thomas Longerich, Jan G. Hengstler, Julio Saez-Rodriguez, Ahmed Ghallab (2022) Transcriptomic cross-species analysis of chronic liver disease reveals a consistent regulation pattern between humans and mice Hepatology Communications Vol.6, 01/2022, 161-177, https://doi.org/10.1002/hep4.1797 Journal impact factor (2019): 5.1 Citations GS (10.2022): 6 |
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2021
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50. |
Ghallab A, Myllys M, Friebel A, Duda J, Edlund K, Halilbasic E, Vucur M, Hobloss Z, Brackhagen L, Begher-Tibbe B, Hassan R, Burke M, Genc E, Frohwein LJ, Hofmann U, Holland CH, González D, Keller M, Seddek A-l, Abbas T, Mohammed ESI, Teufel A, Itzel T, Metzler S, Marchan R, Cadenas C, Watzl C, Nitsche MA, Kappenberg F, Luedde T, Longerich T, Rahnenführer J, Hoehme S, Trauner M, Hengstler JG. (2021) Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression Cells 10(10): 2516. https://doi.org/10.3390/cells10102516 Journal impact factor (2019): 4.8 Citations GS (10.2022): 7 |
49. |
Ahmed Ghallab, Reham Hassan, Maiju Myllys, Wiebke Albrecht, Adrian Friebel, Stefan Hoehme, Ute Hofmann, Abdel-latif Seddek, Albert Braeuning, Lars Kuepffer, Benedikt Cramer, Hans-Ulrich Humpf, Peter Boor, Gisela H. Degen, Jan G. Hengstler (2021) Subcellular Spatio-Temporal Intravital Kinetics of Aflatoxin B1 and Ochratoxin A in Liver and Kidney Archives of Toxicology 2021 Jun;95(6):2163-2177. doi: 10.1007/s00204-021-03073-5. PMID: 34003344. Journal impact factor (2019): 5.1 Citations GS (10.2022): 5 |
48. |
Ahmed Ghallab, Reham Hassan, Maiju Myllys, Adrian Friebel, L Brackhagen, Ute Hofmann, S Sezgin, Abdel-latif Seddek, S Zuehlke, J Reinders, Stefan Hoehme, Jan G. Hengstler (2021) A so far unrecognized mechanism of acetaminophen hepatotoxicity Z Gastroenterol 2021; 59(01): e5. DOI: 10.1055/s-0040-1721954 |
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2020
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47. |
Nachiket Vartak, Georgia Guenther, Florian Joly, Amruta Damle-Vartak, Gudrun Wibbelt, Jörns Fickel, Simone Jörs, Brigitte Begher-Tibbe, Adrian Friebel, Kasimir Wansing, Ahmed Ghallab, Marie Rosselin, Noemie Boissier, Irene Vignon-Clementel, Christian Hedberg, Fabian Geisler, Heribert Hofer, Peter Jansen, Stefan Hoehme, Dirk Drasdo, Jan G Hengstler (2020) Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux Hepatology 2021 Apr;73(4):1531-1550 Journal impact factor (2019): 14.7 Citations GS (10.2022): 23 |
46. |
Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzales Valverde, Steffen Grosser, Stefan Hoehme, Josef Kaes, Dirk Drasdo (2020) A quantitative high resolution computational mechanics cell model for growing and regenerating tissues Biomechanics and Modeling in Mechanobiology (BMMB) 19, 189–220 Citations GS (10.2022): 26 |
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2019
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45. |
Erik Kolbe, Susanne Aleithe, Christiane Rennert, Jan Böttger, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja (2019) Mutual zonated interactions of the Wnt and the Hh signaling are orchestrating the metabolism of the adult liver in mice and human Cell Reports Dec 24;29(13):4553-4567.e7. doi: 10.1016/j.celrep.2019.11.104 Journal impact factor (2018): 7.8 Citations GS (10.2022): 10 |
44. |
Paul Van Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzales Valverde, Steffen Grosser, Stefan Hoehme, Josef Kaes, Dirk Drasdo (2019) A quantitative high resolution computational cell model to unravel the mechanics in living tissues Computer Methods in Biomechanics and Biomedical Engineering 22, 367-369 Citations GS (10.2022): 2 |
43. |
Erik Kolbe, Susanne Aleithe, Christiane Rennert, Jan Böttger, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja (2019) Wnt/β-Catenin and Hh signaling in the adult liver–an insight into distribution, interaction and regulation Zeitschrift für Gastroenterologie 57 01 3-7 |
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2018
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42. |
Daniel Moyo, Lynette Beattie, Paul Andrews, John Moore, Jonathan Timmis, Amy Sawtell, Stefan Hoehme, Adam Sampson, Paul Kaye (2018) Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling Frontiers in Immunology 2018 Mar 27;9:637. doi: 10.3389/fimmu.2018.00637. eCollection 2018. Citations GS (10.2022): 6 |
41. |
Stefan Hoehme, Francois Bertaux, William Weens, Bettina Grasl-Kraupp, Jan G. Hengstler, Dirk Drasdo (2018) Model prediction and validation of an order mechanism controlling the spatio-temporal phenotype of early hepatocellular carcinoma Bulletin of Mathematical Biology 2018 May;80(5):1134-1171. doi: 10.1007/s11538-017-0375-1. Epub 2018 Mar 22. Citations GS (10.2022): 19 |
40. |
Peeters, G., Debbaut, C., Friebel, A., Cornillie, P., De Vos, W. H., Favere, K., Vander Elst, I., Vandecasteele, T., Johann, T., Van Hoorebeke, L., Monbaliu, D., Drasdo, D., Hoehme, S., Laleman, W. and Segers, P. (2018) Quantitative analysis of hepatic macro- and microvascular alterations during cirrhogenesis in the rat J. Anat. 232(3), 485-496, 2018/3/1 Citations GS (10.2022): 27 |
39. |
E Schröder, S Hoehme, J Böttger, S Aleithe, R Gebhardt, M Matz-Soja (2018) Zonation of Morphogens in the adult liver–Crosstalk between Hh and Wnt/β-Catenin signaling Zeitschrift für Gastroenterologie 56 01 A31-97 |
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2017
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38. |
Petru O. Bucur, Mohamed Bekheit, Chloe Audebert, Amnah Othman, Seddik Hammad, Mylene Sebagh, Marc-Antoine Allard, Benoit Decante, Adrian Friebel, Elodie Miquelestorena-Standley, Dirk Drasdo, Jan G. Hengstler, Irene E. Vignon-Clementel, Eric Vibert, Laleman, W. and Segers, P. (2017) Modulating Portal Hemodynamics With Vascular Ring Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model Ann Surg. 2018 Jul;268(1):134-142. doi: 10.1097/SLA.0000000000002146. |
37. |
Marcel Leist, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik Danen, Ben van Ravenzwaay, Hennicke KampIain Gardner, Patricio Godoy, Frederic Y. Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk Drasdo, Stefan Hoehme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost Beltman, Harry Vrieling, Ferran Sanz, Anna Forsby, Domenico Gadaleta, Ciarán Fisher, Jens Kelm, David Fluri, Gerhard Ecker, Barbara Zdrazil, Andrea Terron, Paul Jennings, Bart van der Burg, Steven Dooley, Annemarie H. Meijer, Egon Willighagen, Marvin Martens, Chris Evelo, Enrico Mombelli, Olivier Taboureau, Alberto Mantovani, Barry Hardy, Bjorn Koch, Sylvia EscherChristoph van Thriel, Cristina Cadenas, D. Kroese, Bob van de Water, Jan G. Hengstler (2017) Adverse outcome pathways: opportunities, limitations and open questions Archives of Toxicology, November 2017, Volume 91, Issue 11, pp 3477–3505 Citations GS (10.2022): 272 |
36. |
Geert Peeters, Charlotte Debbaut, Wim Laleman, Adrian Friebel, Diethard Monbaliu, Ingrid Vander Elst, Jan R. Detrez, Tim Vandecasteele, Tim Johann, Thomas De Schryver, Luc Van Hoorebeke, Kasper Favere, Jonas Verbeke, Dirk Drasdo, Stefan Hoehme, Patrick Segers, Pieter Cornillie, Winnok H. De Vos (2017) A multilevel framework to reconstruct anatomical 3D models of the hepatic vasculature in rat livers Journal of Anatomy, Volume 230, Issue 3, 471–483 |
35. |
S. Hoehme, A. Friebel, S. Hammad, D. Drasdo, and J.G. Hengstler (2017) Creation of Three-dimensional Liver Tissue Models from Experimental Images for Systems Medicine in Book Hepatocyte Transplantation (Methods and Protocols) Editors: P. Stock B. Christ, Springer, ISBN 978-1-4939-6504-5 Citations GS (10.2022): 17 |
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2016
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34. |
Samuel H Friedman, Alexander RA Anderson, David M Bortz, Alexander G Fletcher, Hermann B Frieboes, Ahmadreza Ghaffarizadeh, David Robert Grimes, Andrea Hawkins-Daarud, Stefan Hoehme, Edwin F Juarez, Carl Kesselman, Roeland MH Merks, Shannon M Mumenthaler, Paul K Newton, Kerri-Ann Norton, Rishi Rawat, Russell C Rockne, Daniel Ruderman, Jacob Scott, Suzanne S Sindi, Jessica L Sparks, Kristin Swanson, David B Agus, Paul Macklin (2016) MultiCellDS: a standard and a community for sharing multicellular data biorxiv.org // Cold Spring Harbor Labs Journals Citations GS (10.2022): 18 |
33. |
Hoehme S (2016) Der Regeneration der Leber auf der Spur Systembiologie.de Journal, Ausgabe 11 (Download), December 2016, p.66-69 |
32. |
Ghallab, A., Henkel, S.G., Cellière, G., Driesch, D., Hoehme, S., Hofmann, U., Zellmer, S., Godoy, P., Sachinidis, A., Blaszkewicz, M., Reif, R., Marchan, R., Kuepfer, L., Häussinger, D., Drasdo, D., Gebhardt, R., Hengstler, J.G. (2016) Model guided identification and therapeutic implications of an ammonia sink mechanism Journal of Hepatology, April 2016 Volume 64, Issue 4, Pages 860–871 Citations GS (10.2022): 110 |
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2015
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31. |
Friebel A., Neitsch J, Johann T, Hammad S, Henstler JG, Drasdo D, Hoehme S (2015) TiQuant: Software for tissue analysis, quantification and surface reconstruction Bioinformatics, 31 (19): 3234-3236 Citations GS (10.2022): 45 |
30. |
L.A.D'Alessandro, S. Hoehme, A. Henney, D. Drasdo and U. Klingmueller (2015) Unraveling liver complexity from molecular to organ level: Challenges and perspectives Progress in Biophysics and Molecular Biology, 117 (1), 78-86 Citations GS (10.2022): 19 |
29. |
A Othman, A Friebel, S Hoehme, T Johann, B Begher-Tibbe, D Drasdo, JG Hengstler, S Hammad Zonation of Morphogens in the adult liver–Crosstalk between Hh and Wnt/β-Catenin signaling Zeitschrift für Gastroenterologie 53 01 A2 |
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2014
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28. |
Dirk Drasdo, Johannes Bode, Uta Dahmen, Olaf Dirsch, Steven Dooley, Rolf Gebhardt, Ahmed Ghallab, Patricio Godoy, Dieter Häussinger, Seddik Hammad, Stefan Hoehme, Hermann-Georg Holzhütter, Ursula Klingmüller, Lars Kuepfer, Jens Timmer, Marino Zerial, Jan G. Hengstler (2014) The virtual liver: state of the art and future perspectives Archives of Toxicology, December 2014, Volume 88, Issue 12, pp 2071-2075 Citations GS (10.2022): 38 |
27. |
Dirk Drasdo, Stefan Hoehme, Jan G. Hengstler (2014) How predictive quantitative modeling of tissue organization can inform liver disease pathogenesis Journal of Hepatology, 61 (4), 951-956 Citations GS (10.2022): 71 |
26. |
Seddik Hammad*, Stefan Hoehme*, Adrian Friebel*, Iris von Recklinghausen, Amnah Othman, Brigitte Begher-Tibbe, Raymond Reif, Patricio Godoy, Tim Johann, Amruta Vartak, Klaus Golka, Petru O Bucur, Eric Vibert, Rosemarie Marchan, Bruno Christ, Steven Dooley, Christoph Meyer, Iryna Ilkavets, Uta Dahmen, Olaf Dirsch, Jan Böttger, Rolf Gebhardt, Dirk Drasdo*, Jan G Hengstler*. (2014) Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis Archives of Toxicology 04/2014; 88 (5), 1161-1183 Citations GS (10.2022): 124 |
25. |
Schliess, F*, Hoehme, S* Henkel, S*, Ghallab, A*, Driesch, D, Böttger, J, Guthke, R, Pfaff, M, Hengstler, J G, Gebhardt, R, Häussinger, D, Drasdo, D, Zellmer, S. (2014) Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration Hepatology 03/2014; 60 (6), 2040-2051 Citations GS (10.2022): 104 |
24. |
F Schließ, S Hoehme, SG Henkel, A Ghallab, D Driesch, J Boettger, R Guthke, M Pfaff, JG Hengstler, R Gebhardt, D Häussinger, D Drasdo, S Zellmer (2014) Integrierte metabolische und räumlich-zeitliche Modellierung des Ammoniak-Stoffwechsels während der Leber-Schädigung und-Regeneration Zeitschrift für Gastroenterologie 52 01 P3-18 |
23. |
LA D'Alessandro, C Meyer, JG Hengstler, U Klingmüller, S Hoehme, S el Kariem, K Safferling, A Raue, J Timmer, D Drasdo, N Grabe, S Dooley (2014) P117 Holistic approach to unravel functions and regulation of HGF in liver regeneration Journal of Hepatology, 1, 60, 105 Citations GS (10.2022): 2 |
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2013
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22. |
Patricio Godoy, Nicola J Hewitt, Ute Albrecht, Melvin E Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A Budinsky, Britta Burkhardt, Neil R Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E P Goldring, María José Gómez-Lechón, Geny M M Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M Kelm, B Kevin Park, Claus Kordes, Gerd A Kullak-Ublick, Edward L Lecluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J Naisbitt, Andreas K Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H K Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S Weiss, Agata Widera, Courtney G Woods, Jinghai James Xu, Kathy M Yarborough, Jan G Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME Archive für Toxikologie 08/2013; DOI:10.1007/s00204-013-1078-5 Citations GS (10.2022): 1181 |
21. |
Dirk Drasdo, Stefan Hoehme, Jan G Hengstler (2013) Modeling of Liver Regeneration Encyclopedia of Systems Biology Dubitzky, W.; Wolkenhauer, O.; Yokota, H.; Cho, K.-H. (Eds.) Springer New York, 1421-1424 |
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2012
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20. |
Drasdo, D and Hoehme, S. (2012) Modeling the impact of granular embedding media, and pulling versus pushing cells on growing cell clones New Journal of Physics, 14, 055025 Citations GS (10.2022): 56 |
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2011
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19. |
Hengstler, J.G., Godoy, P., Reif, R., Stewart, J., Schug, M., Heise, T., Oberemm, A., Braeuning, A., Zellmer, S., Böttger, J., Gebhardt, R., Hoehme, S., Drasdo, D., Schwarz, M. (2011) The virtual liver. Spatial-temporal modelling of tissue damage & regeneration. In: Seidle T, Spielmann H (Eds.): Alternative testing strategies. Progress report 2011 & AXLR8-2 Workshop report on a ‚Roadmap to innnovative toxicity testing' (pp 218-225). Berlin: AXLR8 Consortium |
18. |
Drasdo, D., Hoehme, S., Hengstler, J. (2011) A quantiative mathematical modeling approach to liver regeneration. In Liver Regeneration. Editor: Dieter Häussinger. De Gruyter Berlin/Boston. Citations GS (10.2022): 3 |
17. |
Hoehme, S., Hammad, S., Othman, A., vonRecklinghausen, I., Boettger, J., Gebhardt, R.,
Dirsch, O., Hengstler, J.G., Drasdo, D. (2011) Modeling liver regeneration in a virtual lobe. Medical Springer Edition |
16. |
JG Hengstler, S Hoehme, R Gebhardt, S Zellmer, D Drasdo (2011) Cell alignment along microvessels as order principle to regenerate tissue architecture: from experiment to virtual tissues and back. Regenerative Medicine, 6, 6, 12 |
15. |
Hengstler J.G., Gehrmann, M., Hoehme S., Drasdo, D., Stewart, J., Schmidt, M. (2011) Systems biology, bioinformatics and medicine approaches to cancer progression outcomes In Cancer Systems Biology, Bioinformatics and Medicine, Cesario, Alfredo; Marcus, Frederick (Eds.), Springer (Read online.) |
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2010
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14. |
Braeuning, A., Singh, Y., B. Rignall, A. Buchmann, S. Hammad, A. Othman, I.v. Recklinghausen, P. Godoy, Hoehme, S., Drasdo, D, Hengstler J.G., Schwarz M. (2010) Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice Histochemistry and Cell Biology, 2010 Nov;134(5):469-81. Citations GS (10.2022): 42 |
13. |
Hoehme, S. and Drasdo D. (2010) A cell-based simulation software for multicellular systems Bioinformatics, 2010 Oct 15;26(20):2641-2. This publication is open access. Citations GS (10.2022): 162 |
12. |
Hoehme, S., Brulport, M., Bauer, A., Bedawy, E., Schormann, W., Gebhardt, R., Zellmer, S., Schwarz, M., Bockamp, E., Timmel, T., G. Hengstler, J.G., and Drasdo, D. (2010). Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration Proc. Natl. Acad. Sci. (USA), 107(23), 10371-10376. The publication is a PNAS open access article. Citations GS (10.2022): 350 // Selected by Faculty of 1000. . |
11. |
Hoehme, S. and Drasdo D. (2010) Biomechanical versus nutrient control: what determines the growth dynamics of mammalian cell populations ? Mathematical Population Studies, 1547-724X, Volume 17, Issue 3, 2010, 166–187. Citations GS (10.2022): 24 |
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2009
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10. |
F Schließ, S Toepfer, S Hoehme, A Bauer, A Krinner, M Brulport, J Boettger, R Guthke, JG Hengstler, D Drasdo, M Pfaff, R Gebhardt, D Häussinger, S Zellmer (2009) Stickstoff-Stoffwechsel während der Leber-Regeneration–Modellierung und Visualisierung Zeitschrift für Gastroenterologie 47 01 P2-34 |
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2008
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9. |
Hoehme, S., Hengstler J.G., Brulport M., Bauer A. and Drasdo D. (2008) Towards modeling liver lobule regeneration in 3D Computational Systems Biology Conference 2008 Proceedings. |
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2007
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8. |
Rohrschneider M., Scheuermann G., Hoehme, S. and Drasdo D. (2007) Shape Characterization of Extracted and Simulated Tumor Samples using Topological and Geometric Measures IEEE Engineering in Medinice and Biology Conference 2007 Proceedings, 2007, 6271-6277. Citations GS (10.2022): 17 |
7. |
Hoehme, S., Hengstler J.G., Brulport M., Schäfer M., Bauer A., Gebhardt R. and Drasdo D. (2007) Mathematical modelling of liver regeneration after intoxication with CCl4 Chemico-Biological Interactions, 168, 74-93 Citations GS (10.2022): 93 |
6. |
Drasdo, D., Hoehme, S. and Block, M. (2007) On the Role of Physics in the Growth and Pattern Formation of Multi-Cellular Systems: What can we Learn from Individual-Cell Based Models? Journal of Statistical Physics, Volume 128, Numbers 1-2, pp. 287-345(59) Citations GS (10.2022): 206 |
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2005
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5. |
Drasdo, D. and Hoehme, S. (2005) A single-cell-based model of tumor growth in vitro: monolayers and spheroids Physical Biology 2 133-147. Citations GS (10.2022): 455 |
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2004
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4. |
Drasdo, D., Dormann, S., Hoehme, S. and Deutsch, A. (2004) Cell-Based Models of Avascular Tumor Growth In: A. Deutsch, M. Falcke, J. Howard, W. Zimmermann (Eds.) Function and Regulation of Cellular Systems: Experiments and Models, 367-378. Birkhäuser Verlag Basel. ISBN 3-7643-6925-6 Citations GS (10.2022): 5 |
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2003
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3. |
Drasdo, D. and Hoehme, S. (2003) Individual-based approaches to birth and death in avascular tumors Mathematical and Computer Modelling, 37 (11), 1163-1175 Citations GS (10.2022): 156 |
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2002
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2. |
Drasdo, D. and Hoehme, S. (2002) How do tumors grow in vitro ? MPI MIS Preprint 114/2002. Citations GS (10.2022): 1 |
1. |
Drasdo, D. and Hoehme, S. (2002) Towards a quantitative single-cell based model approach to growing multicellular spheroids In: Deformable Modeling and Soft Tissue Simulation, Ed. E. Keeve, Ayache, N., Elsevier Science. Citations GS (10.2022): 1 |
Color legend
| (Shared) First/Last author |
| Journal article |
| Book contribution |
Cumulative citations
| 4347 (ISI Web of Knowledge) |
| 4635 (Google Scholar) |
Indices (Hoehme)
| H-Index: 24 |
| i10-Index: 35 |
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Data as of 10/2024
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HoehmeLab